Ford Transit 150 and 350 are cargo vans while the 250 is a passenger wagon.
There are some more differences like:
The 250 and 350 have a high roof option.
The 350 is a cargo van with 9500 GVWR vs 9000 for the 250.
The curb weights are higher for the 350, it is 5743 lbs vs 4985.
The 250 can seat up to to 15 people, the 150 seats 2.
They 150 and 250 have 5300 lbs of towing capacity. The 350 has 5600 lbs.
The 150 starting price is $42k, the 250 is $43k, the 350 is $50k.
All have same engine, a 275 hp turbo v6. The all have same tranny.
The 150 and 250 are 219 inches long, the 350 is 263 inches.
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Video comparing them: